Publications

2023

The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response. Wang G, Laranjeiro R, LeValley S, Van Raamsdonk JM, Driscoll M. Free Radic Biol Med. 2023, September. PMID: 37758122

Overexpression of mitochondrial fusion genes enhances resilience and extends longevity. Annika Traa, Allison Keil, Zenith Rudich, Shusen Zhu, View ORCID ProfileJeremy M. Van Raamsdonk. bioRxiv. 2023, October.

RNA Sequencing of Pooled Samples Effectively Identifies Differentially Expressed Genes. Ko B, Van Raamsdonk JM. Biology (Basel). 2023, Jun. PMID: 37372097

Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity. Abdelrahman AlOkda, Jeremy M Van Raamsdonk. Antioxidants. 2023 May, PMID: 37107319

Biological resilience and aging: activation of stress response pathways contributes to lifespan extension. Sonja K Soo, Zenith D Rudich, Bokang Ko, Alibek Moldakozhayev, Abdelrahman AlOkda, Jeremy M Van Raamsdonk. Ageing Research Reviews. 2023 April. PMID: 37127095

Huntingtin decreases susceptibility to a spontaneous seizure disorder in FVN/B mice. Van Raamsdonk JM, Al-Shekeli H, Wagner L, Bredy TW, Chan L, Pearson J, Schwab C, Murphy Z, Devon RS, Lu G, Kobor MS, Hayden MR, Leavitt BRAging and Disease. 2023 May. PMID: 37199581

Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants. Traa A, Shields H, AlOkda A, Rudich ZD, Ko B, Van Raamsdonk JM. Frontiers in Aging. 2023, May. PMID: 37261067

Endosomal trafficking protein TBC-2 modulates stress resistance and lifespan through DAF-16-dependent and independent mechanisms. Annika Traa, Sonja K Soo, Abdelrahman AlOkda, Bokang Ko, Christian E Rocheleau, Jeremy M Van Raamsdonk. Aging Cell. 2023, February. PMID: 36794357

Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity. Sonja K Soo, Annika Traa, Zenith D Rudich, Alibek Moldakozhayev, Meeta Mistry, Jeremy M Van Raamsdonk. Aging Cell. 2023 February. PMID: 36514863

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics. Juliane Cruz Campos, Luiz Henrique Marchesi Bozi, Barbara Krum, Luiz Roberto Grassmann Bechara, Nikolas Dresch Ferreira, Gabriel Santos Arini, Rudá Prestes Albuquerque, Annika Traa, Takafumi Ogawa, Alexander M van der Bliek, Afshin Beheshti , Edward T Chouchani, Jeremy M Van Raamsdonk, T Keith Blackwell, Julio Cesar Batista Ferreira. Proc Natl Acad Sci U S A. 2023 January. PMID: 36595699

2022

Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models. Laura Lynn Chan, Austin Hill, Ge Lu, Jeremy Van Raamsdonk, Randy Gascoyne, Michael R Hayden, Blair R Leavitt. J Huntingtons Dis. 2022 November. PMID: 36442204

Effect of DMSO on lifespan and physiology in C. elegans : Implications for use of DMSO as a solvent for compound delivery. Abdelrahman AlOkda, Jeremy M Van Raamsdonk. MicroPubl Biol. 2022 September. PMID: 36158529

The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan. İçten Meraş, Laëtitia Chotard, Thomas Liontis, Zakaria Ratemi, Benjamin Wiles, Jung Hwa Seo, Jeremy M Van Raamsdonk, Christian E Rocheleau. PLoS Genet. 2022 August. PMID: 35913999

Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants. Namastheé Harris-Gauthier, Annika Traa, Abdelrahman AlOkda, Alibek Moldakozhayev, Ulrich Anglas, Sonja K Soo, Jeremy M Van Raamsdonk. Redox Biol. 2022 May. PMID: 35598379.

2021

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation. Annika Traa, Emily Machiela, Paige D Rudich, Sonja K Soo, Megan M Senchuk, Jeremy M Van Raamsdonk. Int J Mol Sci. 2021 December. PMID: 34948242.

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling. Juliane C Campos, Ziyun Wu, Paige D Rudich, Sonja K Soo, Meeta Mistry, Julio Cb Ferreira, T Keith Blackwell, Jeremy M Van Raamsdonk. EMBO Rep. 2021 December. PMID: 34617666.

Targeting mitochondrial network disorganization is protective in C. elegans models of Huntington’s disease. Emily Machiela, Paige D Rudich, Annika Traa, Ulrich Anglas, Sonja K Soo, Megan M Senchuk, Jeremy M Van Raamsdonk. Aging Dis. 2021 October. PMID: 34631219.

High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response. Sonja K Soo, Jeremy M. Van Raamsdonk. MicroPubl Biol. 2021 October. PMID: 34693215.

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors. Sonja K Soo, Annika Traa, Paige D Rudich, Meeta Mistry, Jeremy M Van Raamsdonk. Life Sci Alliance. 2021 September. PMID: 34583931.

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies. Hazel J. Shields, Annika Traa, Jeremy M. Van Raamsdonk. Front. Cell Dev. Biol. 2021 February 11. PMID: 33644065.

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease. Megan M Senchuk, Jeremy M Van Raamsdonk, Darren J Moore. Neurobiology of Disease. 2021 January 12. doi: 10.1016/j.nbd.2021.105267. PMID: 33450392.

2020

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Alan A Cohen, Brian K Kennedy, Ulrich Anglas, Anne M Bronikowski, Joris Deelen, Frédérik Dufour, Gerardo Ferbeyre, Luigi Ferrucci, Claudio Franceschi, Daniela Frasca, Bertrand Friguet, Pierrette Gaudreau, Vadim N Gladyshev, Efstathios S Gonos, Vera Gorbunova, Philipp Gut, Mikhail Ivanchenko, Véronique Legault, Jean-François Lemaître, Thomas Liontis, Guang-Hui Liu, Mingxin Liu, Andrea B Maier, Otávio T Nóbrega, Marcel G M Olde Rikkert, Graham Pawelec, Sylvie Rheault, Alistair M Senior, Andreas Simm, Sonja Soo, Annika Traa, Svetlana Ukraintseva, Quentin Vanhaelen, Jeremy M Van Raamsdonk, Jacek M Witkowski, Anatoliy I Yashin, Robert Ziman, Tamàs Fülöp. Mechanisms of Aging and Development. 2020 July 18. doi: 10.1016/j.mad.2020.111316. PMID: 32693105.

Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders. Soo SK, Rudich PD, Traa A, Harris-Gauthier N, Shields HJ, Van Raamsdonk JM. Mechanisms of Aging and Development. 2020 June 28. doi: 10.1016/j.mad.2020.111297. PMID: 32610099.

Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. Machiela E, Liontis T, Dues DJ, Rudich PD, Traa A, Wyman L, Kaufman C, Cooper JF, Lew L, Nadarajan S, Senchuk MM, Van Raamsdonk JM. FASEB J. 2020 May 8. doi: 10.1096/fj.201903235R. PMID: 32385951.

2019

Resistance to Stress Can Be Experimentally Dissociated From Longevity. Dues DJ, Andrews EK, Senchuk MM, Van Raamsdonk JM. J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1206-1214. doi: 10.1093/gerona/gly213.
PMID: 30247515.

2018

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways. Wu Z, Senchuk MM, Dues DJ, Johnson BK, Cooper JF, Lew L, Machiela E, Schaar CE, DeJonge H, Blackwell TK, Van Raamsdonk JM. BMC Biol. 2018 Dec 18;16(1):147. doi: 10.1186/s12915-018-0615-3. PMID: 30563508.

α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease. Cooper JF, Spielbauer KK, Senchuk MM, Nadarajan S, Colaiácovo MP, Van Raamsdonk JM. Exp Neurol. 2018 Dec;310:58-69. doi: 10.1016/j.expneurol.2018.09.001. Epub 2018 Sep 5.
PMID: 30194957.

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. Senchuk MM, Dues DJ, Schaar CE, Johnson BK, Madaj ZB, Bowman MJ, Winn ME, Van Raamsdonk JM. PLoS Genet. 2018 Mar 9;14(3):e1007268. doi: 10.1371/journal.pgen.1007268. eCollection 2018 Mar.
PMID: 29522556.

Modeling Parkinson's Disease in C. elegans. Cooper JF, Van Raamsdonk JM. J Parkinsons Dis. 2018;8(1):17-32. doi: 10.3233/JPD-171258. PMID: 29480229.

Mechanisms underlying longevity: A genetic switch model of aging. Van Raamsdonk JM. Exp Gerontol. 2018 Jul 1;107:136-139. doi: 10.1016/j.exger.2017.08.005. Epub 2017 Aug 7. PMID: 28797825.

2017

Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays. Senchuk MM, Dues DJ, Van Raamsdonk JM. Bio Protoc. 2017 Jan 5;7(1):e2086. doi: 10.21769/BioProtoc.2086. PMID: 29276721.

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models. Cooper JF, Machiela E, Dues DJ, Spielbauer KK, Senchuk MM, Van Raamsdonk JM. Sci Rep. 2017 Nov 27;7(1):16441. doi: 10.1038/s41598-017-16637-2. PMID: 29180793.

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein. Tyson T, Senchuk M, Cooper JF, George S, Van Raamsdonk JM, Brundin P. Sci Rep. 2017 Aug 8;7(1):7506. doi: 10.1038/s41598-017-07383-6. PMID: 28790319.

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans. Dues DJ, Schaar CE, Johnson BK, Bowman MJ, Winn ME, Senchuk MM, Van Raamsdonk JM. Free Radic Biol Med. 2017 Jul;108:362-373. doi: 10.1016/j.freeradbiomed.2017.04.004. Epub 2017 Apr 7. PMID: 28392283.

Oxidative stress in neurodegenerative disease: causation or association? Van Raamsdonk JM, Vega IE, Brundin P. Oncotarget. 2017 Feb 14;8(7):10777-10778. doi: 10.18632/oncotarget.14650. PMID: 28099897.

2016

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease. Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P.
Sci Transl Med. 2016 Dec 7;8(368):368ra174. doi: 10.1126/scitranslmed.aag2210. PMID: 27928028.

Oxidative stress is increased in C. elegans models of Huntington's disease but does not contribute to polyglutamine toxicity phenotypes. Machiela E, Dues DJ, Senchuk MM, Van Raamsdonk JM.
Neurobiol Dis. 2016 Dec;96:1-11. doi: 10.1016/j.nbd.2016.08.008. Epub 2016 Aug 18. PMID: 27544481.

Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways. Dues DJ, Andrews EK, Schaar CE, Bergsma AL, Senchuk MM, Van Raamsdonk JM.
Aging (Albany NY). 2016 Apr;8(4):777-95. doi: 10.18632/aging.100939. PMID: 27053445.

2015

Levels and location are crucial in determining the effect of ROS on lifespan. Van Raamsdonk JM.
Worm. 2015 Oct 2;4(4):e1094607. doi: 10.1080/21624054.2015.1094607. eCollection 2015 Oct-Dec. PMID: 27123369.

Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models. Cooper JF, Dues DJ, Spielbauer KK, Machiela E, Senchuk MM, Van Raamsdonk JM. NPJ Parkinsons Dis. 2015 Nov 19;1:15022. doi: 10.1038/npjparkd.2015.22. eCollection 2015. PMID: 28725688.

Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM. PLoS Genet. 2015 Feb 11;11(2):e1004972. doi: 10.1371/journal.pgen.1004972. eCollection 2015 Feb. PMID: 25671321.